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ChemicalBook--->CAS DataBase List--->1438492-26-2

1438492-26-2

1438492-26-2 Structure

1438492-26-2 Structure
IdentificationBack Directory
[Name]

ciraparantag,Aripazine,PER977
[CAS]

1438492-26-2
[Synonyms]

PER977
PER-977
PER 977
Aripazine
Ciraparantag
PER977; ARIPAZINE
Ciraparantag(PER977)
di-arginine piperazine
ciraparantag,Aripazine,PER977
PER977; ARIPAZINE;PER-977;PER 977
(2S,2'S)-N,N'-(piperazine-1,4-diylbis(propane-3,1-diyl))bis(2-amino-5-guanidinopentanamide)
(2S,2'S)-N,N'-(1,4-Piperazinediyldi-3,1-propanediyl)bis[2-amino-5-[(aminoiminomethyl)amino]pentanamide]
Pentanamide, N,N'-(1,4-piperazinediyldi-3,1-propanediyl)bis[2-amino-5-[(aminoiminomethyl)amino]-, (2S,2'S)-
[Molecular Formula]

C22H48N12O2
[MOL File]

1438492-26-2.mol
[Molecular Weight]

512.7
Chemical PropertiesBack Directory
[density ]

1.37±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

15.11±0.46(Predicted)
[color ]

White to off-white
[Water Solubility ]

Water : ≥ 31 mg/mL (60.46 mM)
Hazard InformationBack Directory
[Uses]

Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban[1][2][3][4].
[storage]

Store at -20°C
[References]

[1] Das A, et al. Novel antidotes for target specific oral anticoagulants. Exp Hematol Oncol. 2015 Sep 15;4:25. DOI:10.1186/s40164-015-0020-3
[2] Gomez-Outes A, et al. Specific antidotes in development for reversal of novel anticoagulants: a review. Recent Pat Cardiovasc Drug Discov. 2014;9(1):2-10. DOI:10.2174/1574890109666141205132531
[3] Hu TY, et al. Reversing anticoagulant effects of novel oral anticoagulants: role of ciraparantag, andexanet alfa, and idarucizumab. Vasc Health Risk Manag. 2016 Feb 17;12:35-44. DOI:10.2147/VHRM.S89130
[4] Honickel M, et al. The Reversal of Direct Oral Anticoagulants in Animal Models. Shock. 2017 Aug;48(2):144-158. DOI:10.1097/SHK.0000000000000848
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