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ChemicalBook--->CAS DataBase List--->143457-40-3

143457-40-3

143457-40-3 Structure

143457-40-3 Structure
IdentificationBack Directory
[Name]

N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE
[CAS]

143457-40-3
[Synonyms]

TAPI-0
TAPI-O
TNF-ALPHA PROTEASE INHIBITOR-0
TNF-ALPHA PROTEASE INHIBITOR-O
TAPI-0 (TNF-± processing inhibitor-0)
HONHCOCH2CH(CH2-CH(CH3)2)CO-NAL-ALA-NH2
N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE
N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-3-(2'-NAPHTHYL) ALANYL-L-ALANINE AMIDE
N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1- oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl- (9CI)
[Molecular Formula]

C24H32N4O5
[MDL Number]

MFCD02684279
[MOL File]

143457-40-3.mol
[Molecular Weight]

456.53
Chemical PropertiesBack Directory
[density ]

1.227±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

50% acetic acid: 1mg/mL
DMSO: 5mg/mL
[form ]

White powder.
[pka]

9.17±0.20(Predicted)
[color ]

white
Hazard InformationBack Directory
[Uses]

TAPI-0 is an inhibitor which blocks the maturation of cytokines, soluble cyokine receptors and other proteins that require the action of proteases.
[Biological Activity]

Cell permeable: no''Primary Target
TNF-α converting enzyme/ADAM17''Product does not compete with ATP.''Reversible: no''Target IC50: 100 nM against TACE (TNF-α converting enzyme/ADAM17)
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