| Chemical Properties | Back Directory | [Boiling point ]
522.5±50.0 °C(Predicted) | [density ]
1.174±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO:40.0(Max Conc. mg/mL);124.0(Max Conc. mM) | [form ]
Solid | [pka]
4.08±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
UCSF924 is a selective, high-affinity dopamine D4 receptor (DRD4) partial agonist (Ki = 3 nM for human D4) with a 7.4-fold bias toward arrestin recruitment over Gαi (Gαi/0; Gi/G0) signaling activation with respect to quinpirole. UCSF924 exhibits no detectable affinity for D2, D3 or the F261V/L328F D4 mutant and no agonist activity toward a panel of 320 nonolfactory GPCRs even at a high concentration of 1 μM. The UCSF924 structure analog UCSF924NC is the recommended negative control compound with a 1/2500-fold reduced D4 affinity. | [Uses]
UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has no off-target effects on more than 320 non-olfactory GPCRs. UCSF924 can be used for research in the field of neuropsychiatric diseases[1][2]. | [IC 50]
D4 Receptor | [References]
[1] Wang S, et al. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 Oct 20;358(6361):381-386. DOI:10.1126/science.aan5468
[2] Thomas G E. Characterizing antipsychotic behavioral and corticostriatal neurophysiological effects to psychotomimetic challenge. Duke University, 2022. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|