| Identification | Back Directory | [Name]
2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one | [CAS]
1434288-24-0 | [Synonyms]
PF-06284674
PF-06284674 >=98% (HPLC)
4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(1H-benzimidazol-1-ylmethyl)-6-methyl-
2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one | [Molecular Formula]
C17H14N4O | [MDL Number]
MFCD29037211 | [MOL File]
1434288-24-0.mol | [Molecular Weight]
290.32 |
| Hazard Information | Back Directory | [Uses]
PF-06284674 (PKM2 activator 1) (Compound 8) is a PKM2 activator that can be used in cancer research[1]. | [Biological Activity]
PF-06284674 is a cell permeablepotent and selective M2 isoform of pyruvate kinase (PKM2) activator. | [References]
[1] Guo C, et al. Discovery of 2-((1H-benzo [d] imidazol-1-yl) methyl)-4H-pyrido [1, 2-a] pyrimidin-4-ones as novel PKM2 activators[J]. Bioorganic & medicinal chemistry letters, 2013, 23(11): 3358-3363. DOI:10.1016/j.bmcl.2013.03.090 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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