| Identification | Back Directory | [Name]
Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- | [CAS]
1431411-66-3 | [Synonyms]
SIRT-IN-2
Inhibitor,SIRT IN 2,inhibit,Sirtuin,SIRTIN2
4-[4-[2-(methanesulfonamido)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide
4-[4-[2-[(methylsulfonyl)amino]ethyl]-1-piperidinyl]-Thieno[3,2-d]pyrimidine-6-carboxamide
Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- | [Molecular Formula]
C15H21N5O3S2 | [MDL Number]
MFCD28386340 | [MOL File]
1431411-66-3.mol | [Molecular Weight]
383.49 |
| Hazard Information | Back Directory | [Description]
SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively. SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1]. | [Uses]
SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively. | [IC 50]
SIRT1: 4 μM (IC50); SIRT2: 1 μM (IC50); SIRT3: 7 μM (IC50) | [storage]
Store at -20°C | [References]
[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79. |
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