| Identification | Back Directory | [Name]
GSK-LSD1 2HCl | [CAS]
1431368-48-7 | [Synonyms]
CS-1628
GSK-LSD
GSK-LSD1
GSK-LSD1 HC'k
GSK-LSD1 2HCl
GSKLSD1 GSK LSD1
GSK-LSD1 2hydrochloride
GSK-LSD1 2HCl USP/EP/BP
GSK-LSD1(LSD1inhibitor)
GSK-LSD1 dihydrochloride
GSK-LSD1 (trans-racemic)
GSK-LSD1 dihydrochloride(GSK-LSD1 2HCl)
GSK-LSD1 (trans-racemic) dihydrochloride
N-[(1R,2S)-2-phenylcyclopropyl]piperidin-4-amine
rel-N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine
4-Piperidinamine, N-[(1R,2S)-2-phenylcyclopropyl]-, rel-
N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine dihydrochloride
rel- N-[(1R,2S)-2-Phenylcyclopropyl]-4-Piperidinamine hydrochloride (1:2) | [Molecular Formula]
C14H22Cl2N2 | [MDL Number]
MFCD28124398 | [MOL File]
1431368-48-7.mol | [Molecular Weight]
216.32 |
| Chemical Properties | Back Directory | [Boiling point ]
347.4±42.0 °C(Predicted) | [density ]
1.07±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble20mg/mL, clear | [form ]
powder | [pka]
10.14±0.10(Predicted) | [color ]
white to beige | [Water Solubility ]
H2O: 20mg/mL, clear |
| Hazard Information | Back Directory | [Uses]
GSK LSD1 Dihydrochloride is an irreversible mechanism-based inhibitor of LSD1. Lysine-specific demthylase 1 (LSD1) belonges to the flavin adenine dinucleotide (FAD) family-dependant amine oxidases that include MAOs and PAOs. Inhibits cell proliferation in cancer cell lines. | [Uses]
GSK-LSD1 has been used as a lysine specific demethylase 1 (LSD1) inhibitor in mice to study sepsis-induced mortality. It has also been used as an inhibitor to study if the effect of phenelzine activation of human immunodeficiency virus (HIV) latency is caused due to LSD1. | [Biological Activity]
gsk-lsd1 2hcl is a selective inhibitor of lsd1 with ic50 value of 16 nm [1].lysine (k) -specific demethylase 1a (lsd1) is a flavin-dependent histone demethylase that demethylates mono- and di-methylated lysines and plays an important role in oocyte growth, embryogenesis and tissue-specific differentiation. lsd1 plays a role in acute myeloid leukemia (aml).gsk-lsd1 2hcl irreversibly inhibited lsd1 with ic50 value of 16 nm and is > 1000 fold selective over lsd2, mao-a and mao-b, which were related to fad utilizing enzymes. in cancer cell lines, gsk-lsd1 2hcl changed gene expression with average ec50 value < 5 nm and inhibited cells growth with average ec50 value < 5 nm. gsk-lsd1 2hcl (10 ?m) inhibited human recombinant dopamine transporter, 5-ht1a and 5-ht transporter by 39%, 49% and 74%, respectively. and no activity against other 55 recombinant receptors (gpcr, transporters, ion channels). gsk-lsd1 2hcl can be used as a chemical probe and a part of the sgc epigenetics [1]. | [Biochem/physiol Actions]
GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. For full characterization details, please visit the GSK-LSD1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc | [References]
[1]. structural genomics consortium.http://www. thesgc.org/chemical-probes/lsd1. |
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