| Identification | Back Directory | [Name]
PROTOVERATRINE A | [CAS]
143-57-7 | [Synonyms]
Nsc7526
Pro-AMid
protalba
Puroverin
Puroverine
protoveratrin
PROTOVERATRINE A
Protofecaterine a
PROTOVERATRINE A (RG)
HYTGGNIMZXFORS-MGYKWWNKSA-N
PROTOPINE HCL(FUMARINE HCL)(RG)(CALL)
6,7-diacetate3-((+)-2-hydroxy-2-methylbutyrate)15-((-)-2-methylbutyrate)
4α,9-Epoxycevane-3β,4,6α,7α,14,15α,16β,20-octol 6,7-diacetate 3-[(S)-2-hydroxy-2-methylbutanoate]15-[(R)-2-methylbutanoate]
[3beta(S),4alpha,6alpha,7alpha,15alpha(R),16beta]-4,9-epoxycevane-3,4,6,7,14,15,16,20-octol 6,7-diacetate 3-(2-hydroxy-2-methylbutyrate) 15-(2-methylbutyrate)
Cevane-3.beta.,4.beta.,6.alpha.,7.alpha.,14,15.alpha.,16.beta.,20-octol, 4,9-epoxy-, 6,7-diacetate 3-((+)-2-hydroxy-2-methylbutyrate) 15-((-)-2-methylbutyrate)
Cevane-3.beta.,4.beta.,6.alpha.,7.alpha.,14,15.alpha.,16.beta.,20-octol, 4,9-epoxy-, 6,7-diacetate, 3-((+)-2-hydroxy-2-methylbutyrate) 15-((-)-2-methylbutyrate)
Cevane-3,4,6,7,14,15,16,20-octol, 4,9-epoxy-, 6,7-diacetate 3-(2-hydroxy-2-methylbutanoate) 15-(2-methylbutanoate), [3.beta.(S),4.alpha.,6.alpha.,7.alpha.,15.alpha.(R),16.beta.]- | [EINECS(EC#)]
205-602-9 | [Molecular Formula]
C41H63NO14 | [MDL Number]
MFCD00135586 | [MOL File]
143-57-7.mol | [Molecular Weight]
793.94 |
| Chemical Properties | Back Directory | [Melting point ]
267-269°C | [alpha ]
D25 -40.5° (pyridine); D25 -10.5° (chloroform) | [Boiling point ]
747.91°C (rough estimate) | [density ]
1.36±0.1 g/cm3 (20 ºC 760 Torr) | [refractive index ]
1.6220 (estimate) | [storage temp. ]
2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [color ]
White |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
26/27/28 | [Safety Statements ]
22-36/37/39-45 | [RIDADR ]
UN 1544 6.1/PG 1 | [WGK Germany ]
3 | [RTECS ]
FL5750100 | [HazardClass ]
6.1(a) | [PackingGroup ]
I | [Toxicity]
LD50 s.c. in male mice: 0.29 mg/kg (Tanaka) |
| Hazard Information | Back Directory | [Description]
A further alkaloid isolated from Veratrum album, this base yields colourless
crystals from EtOH. It is laevorotatory with [α]27D - 44.1° (pyridine) or - 12.1°
(CHC13). Like the preceding base, it dissolves in H2S04 to give a blue colour.
The complex with maleic acid has been prepared as colourless crystals, m.p.
241.5°C; [α]20D - 37.6°. On alkaline hydrolysis, the alkaloid furnishes protoverine, two moles of acetic acid, one mole of (-)-methylbutyric acid and one
mole of (+)-2-hydroxy-2-methylbutyric acid. | [Uses]
Protoveratrine A is a pharmacological agent which displays neuroprotective effects in ischemic stroke. | [Definition]
ChEBI: Protoveratrine A is an alkaloid. | [Brand name]
Protalba (Marion Merrell Dow). | [target]
Calcium Channel | Potassium Channel | [References]
Stoll, Seebeck., Helv. Chim. Acta, 36,718 (1953) |
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