| Identification | Back Directory | [Name]
4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE | [CAS]
14279-91-5 | [Synonyms]
BW 65-100 (hydrochloride)
4-ChlorophenylguanidineHCl
(4-Chlorophenyl)guanidine Hydrochlo
p-Chlorophenylguanidine Hydrochloride
4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE
Chlorhexidine Digluconate EP Impurity E
1-(4-chlorophenyl)guanidine hydrochloride
Chlorhexidine Diacetate Impurity E as Hydrochloride
Chlorhexidine Diacetate EP Impurity E as Hydrochloride | [Molecular Formula]
C7H9Cl2N3 | [MDL Number]
MFCD00209839 | [MOL File]
14279-91-5.mol | [Molecular Weight]
206.07 |
| Chemical Properties | Back Directory | [Melting point ]
237-238 °C(Solv: water (7732-18-5)) | [storage temp. ]
Store at RT | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Pale Green | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
p-Chlorophenylguanidine Hydrochloride is an reagent used in the synthesis of pyrimidine derivatives as hSMG-1 inhibitors, potential targets for cancer treatment. | [Biological Activity]
4-chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase [1].urokinase is a serine protease. its primary physiological substrate is plasminogen, which is an inactive form of plasmin. urokinase plays an important role in vascular diseases and cancer.4-chlorophenylguanidine hydrochloride inhibited urokinase and trypsin with ki value of 6.07 μm and 120 μm, respectively [1]. | [storage]
Store at RT | [References]
[1]. yang h, henkin j, kim kh, et al. selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. j med chem, 1990, 33(11): 2956-2961. |
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BOC Sciences
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https://www.bocsci.com |
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