| Identification | Back Directory | [Name]
3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate | [CAS]
142629-81-0 | [Synonyms]
Azt-pmap
3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate | [Molecular Formula]
C20H25N6O8P | [MDL Number]
MFCD34469291 | [MOL File]
142629-81-0.mol | [Molecular Weight]
508.422 |
| Hazard Information | Back Directory | [Uses]
Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity[1]. AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection[2]. Azt-pmap is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
HIV-1 | [References]
[1] McGuigan C, et al. Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZT. Antiviral Res. 1992 Apr;17(4):311-21. DOI:10.1016/0166-3542(92)90026-2
[2] Gray LR, et al. The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes. PLoS One. 2013 Apr 16;8(4):e62196. DOI:10.1371/journal.pone.0062196 |
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