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ChemicalBook--->CAS DataBase List--->1421936-85-7

1421936-85-7

1421936-85-7 Structure

1421936-85-7 Structure
IdentificationBack Directory
[Name]

[5-Methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[(1R,5R)-1-(5-trifluoromethyl-isoxazol-3-yl)-3-aza-bicyclo[3.1.0]
[CAS]

1421936-85-7
[Synonyms]

Iclepertin
Iclepertin (BI-425809)
[5-Methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[(1R,5R)-1-(5-trifluoromethyl-isoxazol-3-yl)-3-aza-bicyclo
[5-Methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[(1R,5R)-1-(5-trifluoromethyl-isoxazol-3-yl)-3-aza-bicyclo[3.1.0]
Methanone, [5-(methylsulfonyl)-2-[(1R)-2,2,2-trifluoro-1-methylethoxy]phenyl][(1R,5R)-1-[5-(trifluoromethyl)-3-isoxazolyl]-3-azabicyclo[3.1.0]hex-3-yl]-
[EINECS(EC#)]

812-974-1
[Molecular Formula]

C20H18F6N2O5S
[MDL Number]

MFCD34474019
[MOL File]

1421936-85-7.mol
[Molecular Weight]

512.42
Chemical PropertiesBack Directory
[Boiling point ]

605.2±55.0 °C(Predicted)
[density ]

1.508±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

-2.86±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

[5-?(Methylsulfonyl)?-?2-?[(1R)?-?2,?2,?2-?trifluoro-?1-?methylethoxy]?phenyl]?[(1R,?5R)?-?1-?[5-?(trifluoromethyl)?-?3-?isoxazolyl]?-?3-?azabicyclo[3.1.0]?hex-?3-?yl]?-methanone is a solid form of GlyT1 inhibitor.
[in vivo]

Single oral administration of Iclepertin induced a dose-dependent increase of glycine cerebrospinal fluid (CSF) levels. Oral administration of Iclepertin in rats induced a dose‐dependent increase of glycine CSF levels from 30% (0.2 mg/kg, not significant) to 78% (2 mg/kg), relative to vehicle[1].

[IC 50]

GLT1: 5.2 mM (IC50, In rat primary neurons ); GLT1: 5 nM (IC50, In human SK-N-MC cells)
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