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ChemicalBook--->CAS DataBase List--->1418747-15-5

1418747-15-5

1418747-15-5 Structure

1418747-15-5 Structure
IdentificationBack Directory
[Name]

1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester
[CAS]

1418747-15-5
[Synonyms]

1-Boc-3-(4-Oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-azetidine
1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester
[Molecular Formula]

C15H19N5O3
[MOL File]

1418747-15-5.mol
[Molecular Weight]

317.34
Chemical PropertiesBack Directory
[Boiling point ]

490.3±55.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

1.11±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC50?value of 26 μM?in an enzymatic chromogenic assay. AZ3976 is active with an IC50?of 16 μM in a plasma clot lysis assay.?AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay[1].
[References]

[1] Ola Fjellstr?m, et al. Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation. J Biol Chem. 2013 Jan 11;288(2):873-85. DOI:10.1074/jbc.M112.371732
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