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ChemicalBook--->CAS DataBase List--->1407966-77-1

1407966-77-1

1407966-77-1 Structure

1407966-77-1 Structure
IdentificationBack Directory
[Name]

PF 06465469 Discontinued See A191400
[CAS]

1407966-77-1
[Synonyms]

PF 06465469
PF 06465469 Discontinued See A191400
(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-aMino-1H-pyrazolo[3,4-d]pyriMidin-3-yl]-N-(4-isopropyl-5-Methylphenyl)benzaMide
(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide
3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide
Benzamide, 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-
[Molecular Formula]

C32H35N5O2
[MDL Number]

MFCD23381175
[MOL File]

1407966-77-1.mol
[Molecular Weight]

521.653
Chemical PropertiesBack Directory
[Melting point ]

209-212°C
[Boiling point ]

730.2±60.0 °C(Predicted)
[density ]

1.30±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble5mg/mL, clear
[form ]

powder
[pka]

12.83±0.70(Predicted)
[color ]

white to beige
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36/37
[WGK Germany ]

3
Hazard InformationBack Directory
[Chemical Properties]

Beige Solid
[Uses]

(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-5-methylphenyl)benzamide is a potential covalent inhibitor of Interleukin-2 Inducible T Cell KInase (Itk). Itk is a member of the TEC-kinase family and is associated with the induction of T cell proliferation and drives cytokines through NFATc.
[Uses]

PF 06465469 is a covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with nanomolar potency in a whole-blood assay.
[Biological Activity]

PF-06465469 is a potent, covalent inhibitor of the nonreceptor tyrosine kinase Itk (IL-2 inducible T-cell kinase), which is expressed primarily in immune cells, and is strongly upregulated following activation of T-cells. PF-06465469 inhibits Itk enzymatic activity with an IC50 of 2 nM. The compound blocks anti-CD3 induced phosphorylation of PLCg in Jurk at cells (IC50 = 31 nM) and IL-2 production in anti-CD3 stimulated human whole blood (IC50 = 48 nM).
[storage]

Store at +4°C
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