| Identification | Back Directory | [Name]
MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 | [CAS]
140430-53-1 | [Synonyms]
MCA-PLGL-DPA-AR-NH2
MMP-2/MMP-7 SUBSTRATE
MCA-PLGL-DAP(DNP)-AR-NH2
390 MMP FRET SUBSTRATE I
MCA-PLGL-DAP(DNP)-ALA-ARG-NH2
FLUORESCENT PEPTIDE SUBSTRATE I
MMP-2/MMP-7 SUBSTRATE, FLUOROGENIC
MCA-PRO-LEU-GLY-LEU-DPA-ALA-ARG-NH2
MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2
MOCAC-PRO-LEU-GLY-LEU-A2PR(DNP)-ALA-ARG-NH2
31:PN:WO2005051299 SEQID:215 unclaimed sequence
7-methoxycoumarin-4-acetyl-pro-leu-*gly-leu-B-(2,
7-METHOXYCOUMARIN-4-ACETYL-PRO-LEU-*GLY- LEU-B-(2,4-
MOCAC-PRO-LEU-GLY-LEU-[3-DNP-2,3-DAP]-ALA-ARG, AMIDE
MCA-PRO-LEU-GLY-LEU-DAP-ALA-ARG-NH2: MCA-PLGL-DAP-AR-NH2
7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide
7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide
Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (Mca7-MethoxycouMarin-4-acetyl)
MOCAC-PRO-LEU-GLY-LEU-N3-[2,4-DINITROPHENYL]-L-2,3-DIAMINOPROPIONYL-ALA-ARG-NH2
7-Methoxycoumarin-4-acetyl-Pro-Leu-Gly-Leu-β-(2,4-dinitrophenylamino)Ala-Arg amide
7-METHOXYCOUMARIN-4-ACETYL-PRO-LEU-GLY-LEU-DNP-(2,3-DIAMINOPROPIONYL)-ALA-ARG, AMIDE
7-methoxycoumarin-4-acetyl-pro-leu-gly-leu-β-(2,4-dinitrophenylamino)ala-ala-arg amide
7-METHOXYCOUMARIN-4-ACETYL-PRO-LEU-GLY-LEU-BETA-(2,4-DINITROPHENYLAMINO)ALA-ALA-ARG AMIDE
(7-METHOXYCOUMARIN-4-YL)ACETYL-L-PROLYL-L-LEUCYLGLYCYL-L-LEUCYL-[N-BETA-(2,4-DINITROPHENYL)-L-2,3-DIAMINOPROPIONYL]-L-ALANYL-L-ARGININE AMIDE | [Molecular Formula]
C49H68N14O15 | [MDL Number]
MFCD00210687 | [MOL File]
140430-53-1.mol | [Molecular Weight]
1093.15 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
20% acetic acid: 1mg/mL | [form ]
Solid | [pka]
12.99±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2), MMP-7 and MMP-9. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues[1][2]. | [Biological Activity]
Cell permeable: no''Primary Target
Fluorogenic substrate for matrix metalloproteinases (MMPs)''Product does not compete with ATP.''Reversible: no''kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M-¹ sec-¹ for MMP-2 | [storage]
Store at -20°C | [References]
[1] Oneda H, et al. Substrate-dependent activation of thermolysin by salt. Biosci Biotechnol Biochem. 2004 Aug;68(8):1811-3. DOI:10.1271/bbb.68.1811
[2] Oneda H, et al. Inhibitory effects of green tea catechins on the activity of human matrix metalloproteinase 7 (matrilysin). J Biochem. 2003 May;133(5):571-6. DOI:10.1093/jb/mvg073 |
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