| Identification | Back Directory | [Name]
Bromo-PEG1-Acid | [CAS]
1393330-33-0 | [Synonyms]
Bromo-PEG1-Acid
CAS_1393330-33-0
Br-PEG1-CH2CH2COOH
Bromo-PEG1-acid >=95%
Bromo-PEG1-propionic acid
3-(2-Bromoethoxy)propanoic acid
Propanoic acid, 3-(2-bromoethoxy)- | [Molecular Formula]
C5H9BrO3 | [MDL Number]
MFCD22574802 | [MOL File]
1393330-33-0.mol | [Molecular Weight]
197.03 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG1-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bromo-PEG1-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG1-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. | [reaction suitability]
reagent type: linker |
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