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ChemicalBook--->CAS DataBase List--->1392224-59-7

1392224-59-7

1392224-59-7 Structure

1392224-59-7 Structure
IdentificationBack Directory
[Name]

myomiRs-IN-1
[CAS]

1392224-59-7
[Synonyms]

myomiRIN1
myomiR-IN-1
myomiR IN 1
myomiRs-IN-1
myomiR inhibitor 1
myomiR inhibitor-1
[Molecular Formula]

C33H27NO6
[MOL File]

1392224-59-7.mol
[Molecular Weight]

533.57
Chemical PropertiesBack Directory
[Boiling point ]

709.6±60.0 °C(Predicted)
[density ]

1.35±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

DMSO: 50mg/mL
[form ]

solid
[pka]

2.19±0.29(Predicted)
[color ]

pale yellow
Hazard InformationBack Directory
[Description]

myomiR-IN-1 is an inhibitor of myomiRs. It acts by inhibiting the translation of myoD in C2C12 cells without changing the expression level of myoD mRNA and downregulating expression of differentiation markers.
[Uses]

MyomiRs-IN-1 is a myomiRs inhibitor with activity to inhibit myoD translation in C2C12 cells. MyomiRs-IN-1 does not change the expression level of myoD mRNA, while downregulating the expression of differentiation markers. MyomiRs-IN-1 affects the expression of myomiRs in muscle cells by regulating the regulatory pathway between miR-221/222 and myoD. The application of MyomiRs-IN-1 can facilitate research on muscle development and related diseases[1].
[References]

[1] Small molecule inhibitor of myogenic microRNAs leads to a discovery of miR-221/222-myoD-myomiRs regulatory pathway
1392224-59-7 suppliers list
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