Identification | Back Directory | [Name]
myomiRs-IN-1 | [CAS]
1392224-59-7 | [Synonyms]
myomiRIN1 myomiR-IN-1 myomiR IN 1 myomiRs-IN-1 myomiR inhibitor 1 myomiR inhibitor-1 | [Molecular Formula]
C33H27NO6 | [MOL File]
1392224-59-7.mol | [Molecular Weight]
533.57 |
Chemical Properties | Back Directory | [Boiling point ]
709.6±60.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 50mg/mL | [form ]
solid | [pka]
2.19±0.29(Predicted) | [color ]
pale yellow |
Hazard Information | Back Directory | [Description]
myomiR-IN-1 is an inhibitor of myomiRs. It acts by inhibiting the translation of myoD in C2C12 cells without changing the expression level of myoD mRNA and downregulating expression of differentiation markers. | [Uses]
MyomiRs-IN-1 is a myomiRs inhibitor with activity to inhibit myoD translation in C2C12 cells. MyomiRs-IN-1 does not change the expression level of myoD mRNA, while downregulating the expression of differentiation markers. MyomiRs-IN-1 affects the expression of myomiRs in muscle cells by regulating the regulatory pathway between miR-221/222 and myoD. The application of MyomiRs-IN-1 can facilitate research on muscle development and related diseases[1]. | [References]
[1] Small molecule inhibitor of myogenic microRNAs leads to a discovery of miR-221/222-myoD-myomiRs regulatory pathway |
|
Company Name: |
Merck KGaA
|
Tel: |
21-20338288 |
Website: |
www.sigmaaldrich.cn |
|