| Identification | Back Directory | [Name]
Propargyl-PEG1-SS-alcohol | [CAS]
1391914-41-2 | [Synonyms]
Propargyl-PEG1-SS-alcohol
Ethanol, 2-[[2-(2-propyn-1-yloxy)ethyl]dithio]- | [Molecular Formula]
C7H12O2S2 | [MDL Number]
MFCD28505558 | [MOL File]
1391914-41-2.mol | [Molecular Weight]
192.3 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG1-SS-alcohol is a Click Chemistry-ready crosslinker containing a propargyl group, a hydroxyl group and a cleavable disulfide bond. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | [Uses]
Propargyl-PEG1-SS-alcohol is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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