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ChemicalBook--->CAS DataBase List--->1380424-42-9

1380424-42-9

1380424-42-9 Structure

1380424-42-9 Structure
IdentificationBack Directory
[Name]

KML-29
[CAS]

1380424-42-9
[Synonyms]

KML-29
CS-2396
KML29 (KML-29)
KML29;KML-29;KML 29
4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
[Molecular Formula]

C24H21F6NO7
[MDL Number]

MFCD22987957
[MOL File]

1380424-42-9.mol
[Molecular Weight]

549.42
Chemical PropertiesBack Directory
[Melting point ]

204-206°C
[Boiling point ]

554.8±50.0 °C(Predicted)
[density ]

1.511±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C Freezer
[solubility ]

Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
[form ]

Solid
[pka]

13.32±0.29(Predicted)
[color ]

White to Off-White
Hazard InformationBack Directory
[Description]

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 (Item No. 13158) that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM). At 5-20 mg/kg, KML29 dose-dependently blocks mouse brain MAGL activity in vivo, without any measurable effect on FAAH activity. As a second generation MAGL inhibitor, KML29 supersedes the low-level cross reactivity that JZL 184 displays for FAAH yet still maintains comparable potency to its parent compound.
[Uses]

KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid.
[storage]

Store at -20°C
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