| Identification | Back Directory | [Name]
CAY10625 | [CAS]
137346-42-0 | [Synonyms]
CAY10625
7-nitro-10-octyl-3-phenylpyrimido[4,5-b]quinoline-2,4-dione
Pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione, 7-nitro-10-octyl-3-phenyl- | [Molecular Formula]
C25H26N4O4 | [MOL File]
137346-42-0.mol | [Molecular Weight]
446.5 |
| Hazard Information | Back Directory | [Description]
Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/DIABLO, caspase-3, and caspase-7.1,2 Survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. CAY10625 is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO, exhibiting an IC50 value of 2.2 μM.3 It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 μM. CAY10625 is cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.3 | [Uses]
Antitumor agent-144 (16) is an antitumor agent, with IC50 values of 2.6 μM and 8.4 μM in L1210 and KB cells, respectively[1]. | [Definition]
ChEBI: CAY10625 is a nitro compound and a member of quinolines. | [storage]
Store at -20°C | [References]
1. Ryan, B.M., O'Donovan, N., and Duffy, M.J. Survivin: A new target for anti-cancer therapy Cancer Treat. Rev. 35,553-562(2009).
2. Shin, S., Sung, B.J., Cho, Y.S., et al. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7 Biochemistry 40,1117-1123(2001).
3. Oikawa, T., Unno, Y., Matsuno, K., et al. Identification of a small-molecule inhibitor of the interaction between Survivin and Smac/DIABLO Biochem. Biophys. Res. Commun. 393,253-258(2010). |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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