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ChemicalBook--->CAS DataBase List--->137275-80-0

137275-80-0

137275-80-0 Structure

137275-80-0 Structure
IdentificationBack Directory
[Name]

5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride
[CAS]

137275-80-0
[Synonyms]

MCI242
MN-305
MCI-242
Osemozotan HCl
Osemozotan hydrochloride
5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride
[Molecular Formula]

C19H22ClNO5
[MDL Number]

MFCD00905894
[MOL File]

137275-80-0.mol
[Molecular Weight]

379.835
Hazard InformationBack Directory
[Uses]

Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder[1][2].
[in vivo]

Osemozotan hydrochloride (1 mg/kg; i.p.; 20 min after picrotoxin treatment) ameliorates picrotoxin-induced decrease in female preference with the combination of (+)-SKF-10,047[1]. Osemozotan hydrochloride (1 mg/kg; i.p.; once) decreases the number of c-Fos-positive cells caused by MAMP[2].

Animal Model:Female CD-1 mice with picrotoxin-induced decrease in female preference[1]
Dosage:1 mg/kg
Administration:Intraperitoneal injection; 1 mg/kg; 20 min after picrotoxin treatment
Result:Ameliorated the picrotoxin-induced decrease in the female preference by co-administration WITH (+)-SKF-10,047 (5 mg/kg). Showed no effect on the picrotoxin-induced decrease in the female preference when treated alone.
Animal Model:ICR mice with MAMP injection[2]
Dosage:1 mg/kg
Administration:Intraperitoneal injection; 1 mg/kg; once
Result:Significantly decreased the number of c-Fos-positive cells induced by MAMP in the medial prefrontal cortex and striatum, but did not change the number of c-Fos-positive cells.
[References]

[1] Hasebe S, et al. Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. Br J Pharmacol. 2017 Feb;174(4):314-327. DOI:10.1111/bph.13692
[2] Tsuchida R, et al. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32(4):728-31. DOI:10.1248/bpb.32.728
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