Identification | Back Directory | [Name]
5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride | [CAS]
137275-80-0 | [Synonyms]
MCI242 MN-305 MCI-242 Osemozotan HCl Osemozotan hydrochloride 5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride | [Molecular Formula]
C19H22ClNO5 | [MDL Number]
MFCD00905894 | [MOL File]
137275-80-0.mol | [Molecular Weight]
379.835 |
Hazard Information | Back Directory | [Uses]
Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder[1][2]. | [in vivo]
Osemozotan hydrochloride (1 mg/kg; i.p.; 20 min after picrotoxin treatment) ameliorates picrotoxin-induced decrease in female preference with the combination of (+)-SKF-10,047[1].
Osemozotan hydrochloride (1 mg/kg; i.p.; once) decreases the number of c-Fos-positive cells caused by MAMP[2]. Animal Model: | Female CD-1 mice with picrotoxin-induced decrease in female preference[1] | Dosage: | 1 mg/kg | Administration: | Intraperitoneal injection; 1 mg/kg; 20 min after picrotoxin treatment | Result: | Ameliorated the picrotoxin-induced decrease in the female preference by co-administration WITH (+)-SKF-10,047 (5 mg/kg). Showed no effect on the picrotoxin-induced decrease in the female preference when treated alone.
|
Animal Model: | ICR mice with MAMP injection[2] | Dosage: | 1 mg/kg | Administration: | Intraperitoneal injection; 1 mg/kg; once | Result: | Significantly decreased the number of c-Fos-positive cells induced by MAMP in the medial prefrontal cortex and striatum, but did not change the number of c-Fos-positive cells.
|
| [References]
[1] Hasebe S, et al. Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. Br J Pharmacol. 2017 Feb;174(4):314-327. DOI:10.1111/bph.13692 [2] Tsuchida R, et al. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32(4):728-31. DOI:10.1248/bpb.32.728 |
|
|