| Identification | Back Directory | [Name]
SSE15206 | [CAS]
1370046-40-4 | [Synonyms]
SSE15206
SSE-15206;SSE 15206
SSE15206; SSE-15206; SSE 15206;1370046-40-4
4,5-Dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide
3-Phenyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
1H-Pyrazole-1-carbothioamide, 4,5-dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)- | [Molecular Formula]
C19H21N3O3S | [MDL Number]
MFCD31746881 | [MOL File]
1370046-40-4.mol | [Molecular Weight]
371.45 |
| Chemical Properties | Back Directory | [Boiling point ]
518.7±60.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO:112.0(Max Conc. mg/mL);301.52(Max Conc. mM) | [form ]
Solid | [pka]
14.12±0.60(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells[1]. | [References]
[1] Manzoor S, et al. Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance. Sci Rep. 2018 Feb 19;8(1):3305. DOI:10.1038/s41598-018-21642-0 |
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BOC Sciences
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16314854226 |
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www.bocsci.com |
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