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ChemicalBook--->CAS DataBase List--->1366233-41-1

1366233-41-1

1366233-41-1 Structure

1366233-41-1 Structure
IdentificationBack Directory
[Name]

GSK255B)
[CAS]

1366233-41-1
[Synonyms]

GSK255B)
GSK 2332255B (GSK2332255B
[Molecular Formula]

C18H19ClFN3O3S
[MDL Number]

MFCD34469310
[MOL File]

1366233-41-1.mol
[Molecular Weight]

411.88
Chemical PropertiesBack Directory
[Boiling point ]

542.7±60.0 °C(Predicted)
[density ]

1.417±0.06 g/cm3(Predicted)
[pka]

0.46±0.10(Predicted)
Hazard InformationBack Directory
[Description]

GSK 2332255B is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 3 nM/21 nM, respectively. It dispalys >100-fold selectivity over other calcium-permeable channels. It has 100-fold greater potency for TRPC3 compared with Pyr3. GSK 2332255B (dose-dependent) blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes.
[Uses]

GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels[1].
[IC 50]

rTRPC3: 5 nM (IC50); rTRPC6: 4 nM (IC50)
[References]

[1] Kinya Seo, et al. Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1551-6. DOI:10.1073/pnas.1308963111
1366233-41-1 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Tags:1366233-41-1 Related Product Information

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