| Identification | Back Directory | [Name]
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE | [CAS]
136132-67-7 | [Synonyms]
CPSB
CTSB
z-rr-amc
APP secretase
Z-RR-AMC, 2HCL
Z-ARG-ARG-MCA.HCL
Z-ARG-ARG-AMC 2HCL
Z-Arg-Arg-AMC/Z-RR-AMC
Cathepsin B Active human
Z-ARG-ARG-MCA HYDROCHLORIDE
Z-ARG-ARG-AMC HYDROCHLORIDE SALT
Z-ARG-ARG-MCA(HYDROCHLORIDE FORM)
Z-Arg-Arg-7-amido-4-methylcoumarin
CATHEPSIN B SUBSTRATE IV, FLUOROGENIC
CATHEPSIN B SUBSTRATE III, FLUOROGENIC
Z-ARG-ARG-7-AMIDO-4-METHYL COUMARIN, DIHCL
ANTI-CATB (CENTER) antibody produced in rabbit
z-arg-arg-7-amido-4-methylcoumarin hydrochloride
na-cbz-arg-arg 7-amido-4-methylcoumarin hydrochlo
CBZ-Arg-Arg-7-amido-4-methylcoumarin hydrochloride
Recombinant Human Cathepsin B/CTSB Protein, His Tag
Recombinant Mouse Cathepsin B/Ctsb Protein, His Tag
NA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORI
N-CBZ-ILE-GLU-THR-ASP-7-AMINO-4- TRIFLUO ROMETHYLCOU
Z-L-ARGINYL-L-ARGININE-7-AMIDO-4-METHYLCOUMARIN 2HCL
Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,Z-RR-AMC
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE USP/EP/BP
BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE | [Molecular Formula]
C30H40ClN9O6 | [MDL Number]
MFCD00133576 | [MOL File]
136132-67-7.mol | [Molecular Weight]
658.15 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: 5mg/mL
water: soluble | [form ]
aqueous solution | [color ]
White to off-white | [biological source]
human | [Water Solubility ]
water: soluble | [Specific Activity]
≥2228pmol/min-μg |
| Hazard Information | Back Directory | [Uses]
Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:
- as a cathepsin B substrate in zymography analysis of protease in feces extract.
- in cathepsin B activity assay.
- as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.
| [General Description]
Human cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide(amino acids 1-16) + Cathepsin B (amino acids 18-339), with C-terminal HIS tag, MW = 43 kDa, expressed in FreeStyle 293-F cells. Cathepsin B is a cysteine protease, found in the lysosome of normal cells and tissues. Cathepsin B active human is encoded by the gene CTSB, located on human chromosome 8p23.1. | [Biochem/physiol Actions]
Cathepsin B Active human primarily is a preproenzyme, glycosylated on rough endoplasmic reticulum. Processing of procathepsin B to a 31 kDa, single chain active form occurs in the lysosome. It is further processed to double chain form with a 25/26 kDa heavy chain and 5 kDa heavy chain in lysosome. Cathepsin B, functions as an exopeptidase at low pH. At higher pH in endosomes or neutral pH, cathepsin B functions as endopeptidase. Cathepsin B expression is upregulated in malignant tumors and facilitates tumor invasion. Cathepsin B might reduce the production of amyloid-β peptide associated with Alzheimerβs disease. It also plays a key role in neuroprotective functions. |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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