| Identification | Back Directory | [Name]
Bis-Propargyl-PEG10 | [CAS]
1351373-47-1 | [Synonyms]
CAS_1351373-47-1
Bis-Propargyl-PEG10
4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne | [Molecular Formula]
C24H42O10 | [MDL Number]
MFCD28976686 | [MOL File]
1351373-47-1.mol | [Molecular Weight]
490.58 |
| Hazard Information | Back Directory | [Description]
Bis-propargyl-PEG10 is reactive with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry. By introducing PEG units into the molecule, the solubility of the compound in aqueous environment can be improved. | [Uses]
Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands[1]. Bis-propargyl-PEG9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Shan M, et al. Conformational analysis of bivalent estrogen receptor ligands: from intramolecular to intermolecular binding. Chembiochem. 2011 Nov 25;12(17):2587-98. DOI:10.1002/cbic.201100529 |
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