天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->1346547-00-9

1346547-00-9

1346547-00-9 Structure

1346547-00-9 Structure
IdentificationBack Directory
[Name]

GSK583
[CAS]

1346547-00-9
[Synonyms]

SK583
GSK583
CS-2216
GSK583, >98%
GSK-583;GSK 583
GSK583 >=98% (HPLC)
RIP2 kinase inhibitor 583
6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine
4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-
[Molecular Formula]

C20H19FN4O2S
[MDL Number]

MFCD30343846
[MOL File]

1346547-00-9.mol
[Molecular Weight]

398.45
Chemical PropertiesBack Directory
[Boiling point ]

652.9±55.0 °C(Predicted)
[density ]

1.402±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,2-8°C
[solubility ]

Soluble in DMSO (up to at least 25 mg/ml).
[form ]

solid
[pka]

12.59±0.40(Predicted)
[color ]

Pale yellow
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50?= 5 nM human and IC50?= 2 nM rat.1?It also potently inhibits isolated RIP3 kinase (IC50?= 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2
[Uses]

GSK 583, is a selective inhibitor of RIP-like interacting CLARP kinase RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines.
[storage]

Store at +4°C
[References]

1) Haile?et al.?(2016),?The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine; J. Med. Chem.,?59?4867 2) Goncharov?et al.?(2018),?Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling; Mol. Cell,?69?551
Spectrum DetailBack Directory
[Spectrum Detail]

GSK583(1346547-00-9)1HNMR
1346547-00-9 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: BOC Sciences
Tel: +1-631-485-4226
Website: www.bocsci.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471 , +1-2135480471
Website: https://www.sarms4muscle.com
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054 , 13417589054
Website: m.approvedhomemanagement.com/ShowSupplierProductsList1962465/0.htm
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139 , +8613720134139
Website: http://www.jknbiochem.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghai JiYi Biotechnology Co. Ltd.  Gold
Tel: 13621943973
Website: m.approvedhomemanagement.com/ShowSupplierProductsList16460/0.htm
Company Name: Suzhou Ran enzyme Biotechnology Co., Ltd.  Gold
Tel: 0512-0512-62793604 18015430729
Website: http://m.approvedhomemanagement.com/ShowSupplierProductsList30224/0.htm
Company Name: Jingmo (Xiamen) Biotechnology Co., Ltd  Gold
Tel: 13621943973; 13621943973
Website: http://www.jamxmpharmatech.com/
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Website: www.boylechem.com
Company Name: Dalian Meilun Biotech Co., Ltd.  
Tel: 0411-62910999 13889544652
Website: www.meilunbio.com/
Tags:1346547-00-9 Related Product Information
19542-67-7 554-62-1 5508-58-7 21256-18-8 1627856-64-7 1346572-63-1 1652591-81-5 1010411-21-8 929095-18-1 2226735-55-1 1628332-52-4 1622849-58-4 1616392-22-3 188591-46-0

This site uses cookies
This website uses cookies and similar technologies to store and retrieve information about your use of this website. This information helps us to provide, analyse and improve our services, which may include personalised content or advertising. We may share this information with Google and other third parties. This cookies are necessary for our website to work properly . By clicking "Continue" or continuing to browse our site you are agreeing to our and our partners use of cookies.
Accept