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ChemicalBook--->CAS DataBase List--->133972-52-8

133972-52-8

133972-52-8 Structure

133972-52-8 Structure
IdentificationBack Directory
[Name]

BIG ENDOTHELIN-1 (1-31) (HUMAN, BOVINE)
[CAS]

133972-52-8
[Synonyms]

ENDOTHELIN-1 (1-31) (HUMAN)
1-31-Human big endothelin 1
BIG ET-1 (1-31) (HUMAN, BOVINE)
BIG ENDOTHELIN-1 (1-31) (HUMAN, BOVINE)
BIG ET-1 (1-31) (HUMAN, BOVINE) TRIFLUOROACETATE SALT
BIG ENDOTHELIN-1 (1-31) (HUMAN, BOVINE) TRIFLUOROACETATE SALT
Big Endothelin-1 (1-31) (huMan, bovine) Big ET-1 (1-31) (huMan, bovine)
CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR
H-CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR-OH
Endothelin 1 (swine), 21a-L-valine-21b-L-asparagine-21c-L-threonine-21d-L-proline-21e-L-glutamic acid-21f-L-histidine-21g-L-valine-21h-L-valine-21i-L-proline-21j-L-tyrosine-
Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-OH trifluoroacetate salt (Disulfide bonds between Cys1 and Cys15/Cys3 and Cys11)
[Molecular Formula]

C162H236N38O47S5
[MDL Number]

MFCD01866298
[MOL File]

133972-52-8.mol
[Molecular Weight]

3628.16
Chemical PropertiesBack Directory
[storage temp. ]

-15°C
Hazard InformationBack Directory
[Uses]

Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase[1].
[in vivo]

ET-1 (1-31) (100 nM; single dose) induces contraction in the mouse mesenteric artery. The contraction may be mediated by the ETA receptor and may be increased by aging. A clear difference exists between males and females in the present chronic diabetic condition[1].

Animal Model:ICR mice, Streptozocin (HY-13753)-induced diabetic model[1]
Dosage:100 nM
Administration:In the organ bath, single dose
Result:In the 1-week control (but not diabetic) group, induced contraction and the contractile response was significantly greater in female mice than in male mice, and there was no significant difference in either male or female mice between the age-matched controls and the diabetic mice. In the 8-weeks group, the contraction was or tended to be increased compared with the corresponding 1-week group in all mice. Although in male mice this contraction was not different between control and diabetic groups, it was significantly greater in diabetic female mice than in the control female mice and in female diabetic mice than in male diabetic mice. The contraction was inhibited by ETA receptor inhibitor.
[References]

[1] Matsumoto T, et al. Gender differences in vascular reactivity to endothelin-1 (1-31) in mesenteric arteries from diabetic mice. Peptides. 2008 Aug;29(8):1338-46. DOI:10.1016/j.peptides.2008.04.001
[2] Yoshizumi M, et al. Effect of endothelin-1 (1-31) on human mesangial cell proliferation. Jpn J Pharmacol. 2000 Oct;84(2):146-55. DOI:10.1254/jjp.84.146
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