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ChemicalBook--->CAS DataBase List--->133550-37-5

133550-37-5

133550-37-5 Structure

133550-37-5 Structure
IdentificationBack Directory
[Name]

TYRPHOSTIN AG 835
[CAS]

133550-37-5
[Synonyms]

AG 835
TYRPHOSTIN B50
(+)-Enantiomer
TYRPHOSTIN B50(+)
TYRPHOSTIN AG 835
(+)-Tyrphostin B44
TYRPHOSTIN B44, (+) ENANTIOMER
Tyrphostin B44, (+) enantiomer AG835
(S)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)acrylamide
ALPHA-CYANO-(+)-(S)-N-(ALPHA-PHENETHYL)-(3,4-DIHYDROXY)CINNAMIDE
(+)-(s)-n-(α-methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
(+)-(S)-N-(ALPHA-METHYLBENZYL)-3,4-DIHYDROXY-BENZYLIDENECYANOACETAMIDE
(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide
(2E)-2-Cyano-3-(3,4-Dihydroxyphenyl)-N-[(1S)-1-Phenylethyl]-2-Propenamide
(S)-(E)-2-CYANO-3-(3',4'-DIHYDROXYPHENYL)-N-(1-PHENYLETHYL)-2-PROPENAMIDE
2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]-, (2E)-
Tyrphostin B50, (+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
non-metastatic tumors,INBL,antitumor,(+)-Tyrphostin B44,Epidermal growth factor receptor,Tyrphostin B50,ErbB-1,Tyrphostin B-44, (+) enantiomer,Inhibitor,Tyrphostin B 50,CALO,cervical carcinoma cell,EGFR,inhibit,Tyrphostin B44, (+) enantiomer,Tyrphostin AG835,HER1,Tyrphostin AG-835,Tyrphostin AG 835,Tyrphostin B-50
[Molecular Formula]

C18H16N2O3
[MDL Number]

MFCD00209855
[MOL File]

133550-37-5.mol
[Molecular Weight]

308.33
Chemical PropertiesBack Directory
[Melting point ]

146 °C
[storage temp. ]

−20°C
[solubility ]

DMSO or ethanol: soluble
[form ]

powder to crystal
[color ]

Light yellow to Amber to Dark green
Safety DataBack Directory
[Symbol(GHS) ]


GHS08
[Signal word ]

Warning
[Hazard statements ]

H371-H373
[Precautionary statements ]

P501-P260-P270-P264-P308+P311-P405
[Safety Statements ]

22-24/25
[WGK Germany ]

3
[HS Code ]

2926.90.4801
Hazard InformationBack Directory
[Uses]

Tyrphostin B44, (+) enantiomer is an EGFR kinase inhibitor.
[Biological Activity]

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 0.86 μ M). Slightly less active than the (-) enantiomer ((R)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide ).
[storage]

Store at -20°C
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