| Identification | Back Directory | [Name]
PROSTAGLANDIN B1 | [CAS]
13345-51-2 | [Synonyms]
PGB1
PGE1-278
15-epi-PGB1
PROSTAGLANDIN B1
PROSTAGLANDINS B1
Prostaglandin E1-278
PGB1 (Prostaglandin B1)
Prostaglandin Impurity B
(-)-(E)-Prostaglandin E1-278
Alprostadil (Prostaglandin E1) EP Impurity B
9-OXO-15S-HYDROXY-PROSTA-8(12),13E-DIEN-1-OIC ACID
[13E,15S]-15-HYDROXY-9-OXOPROSTA-8[12],13-DIEN-1-OIC ACID
Prosta-8(12),13-dien-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)-
(13E,15S)-15-Hydroxy-9-oxoprosta-8(12),13-dien-1-oic acid, PGB1
[13E,15R,(+)]-15-Hydroxy-9-oxo-8,12-didehydroprost-13-en-1-oic acid
7-[2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-1-cyclopentenyl]heptanoic acid
(+)-2-[(E,R)-3-Hydroxy-1-octenyl]-5-oxo-1-cyclopentene-1-heptanoic acid
ProstaglandinB1,(13E,15S)-15-Hydroxy-9-oxoprosta-8(12),13-dien-1-oic acid, PGB1
Prostaglandin B1 ((13E,15S)-15-Hydroxy-9-oxoprosta-8(12),13-dien-1-oic Acid) (1578554) | [EINECS(EC#)]
234-237-8 | [Molecular Formula]
C20H32O4 | [MDL Number]
MFCD00036679 | [MOL File]
13345-51-2.mol | [Molecular Weight]
336.47 |
| Chemical Properties | Back Directory | [Melting point ]
69-71°C | [Boiling point ]
531.4±43.0 °C(Predicted) | [density ]
1.101±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
acetone: 20 mg/mL, clear, colorless to very faintly yellow
| [form ]
powder
| [pka]
4.77±0.10(Predicted) | [color ]
white to light yellow
| [biological source]
synthetic | [BRN ]
2004447 | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
Biosynthesis from dihomo-γ-linolenic acid. | [Definition]
ChEBI: Prostaglandin B1 is a member of the class of prostaglandins B that is prosta-8(12),13-dien-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 13E,15S-stereoisomer). It has a role as a human metabolite. It is a conjugate acid of a prostaglandin B1(1-). | [Biological Activity]
Prostaglandin B1 (PGB1) is a metabolic product of PGE1 dehydration. It is known to specifically bind to peroxisome proliferator-activated receptor-γ. By thisPGB1 mediates f at accumulation and metabolism. Oligomerization of PGB1 potentiates its anti-oxidative property. | [Enzyme inhibitor]
This eicosanoid (FWB1 (free-acid) = 336.47 g/mol; CAS 13345-51-2, for PGB1,
and 39306-29-1, for Bx) is a metabolite of prostaglandin E1: prostaglandin
Bx is an oligomer of prostaglandin B1. The X-ray crystal structure of
prostaglandin B1 suggests this prostaglandin has an unusual L-shaped
configuration, with the a and w side chains roughly perpendicular to one
another. The 15-hydroxyl group, which is normally directed away from
the centroid of the prostaglandin in the standard hairpin mod+el, is turned
inward in prostaglandin B1. Target (s) : FoF1 ATPase, or H-transporting
two-sector ATPase, inhibited by prostaglandin Bx; 15-
hydroxyprostaglandin dehydrogenase; phospholipase A2, inhibited by
prostaglandin Bx. |
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| Website: |
www.bocsci.com |
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