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ChemicalBook--->CAS DataBase List--->133156-06-6

133156-06-6

133156-06-6 Structure

133156-06-6 Structure
IdentificationBack Directory
[Name]

DELTA-AMINOVALERYL-PHE-PHE-PRO-N-ME-LEU-MET-NH2
[CAS]

133156-06-6
[Synonyms]

GR 73632
GR-73632 (GR73632)
H2H-(CH2)4-CO-PHE-PRO-NME-LEU-MET-NH2
d-AMinovaleryl-Phe-Phe-Pro-N-Me-Leu-Met-NH2
DELTA-AMINOVALERYL-PHE-PHE-PRO-N-ME-LEU-MET-NH2
d-AMinovaleryl-(Pro9,N-Me-Leu10)-Substance P (7-11)
DELTA-AMINOVALERYL-(PRO9,N-ME-LEU10)-SUBSTANCE P (7-11)
(DELTA-AMINOVALERYL6,PRO9,N-ME-LEU10)-SUBSTANCE P (6-11)
δ-Aminovaleryl-[Pro9, Leu(N-Me)10]-SubstanceP Fragment 7-11
N-(5-Amino-1-oxopentyl)-L-Phe-L-Phe-L-Pro-N-methyl-L-Leu-L-Met-NH2
L-Methioninamide,N-(5-amino-1-oxopentyl)-L-phenylalanyl-L-phenylalanyl-L-prolyl-N-methyl-L-leucyl-
(2S)-1-[(2S)-2-[[(2S)-2-(5-aminopentanoylamino)-3-phenyl-propanoyl]amino]-3-phenyl-propanoyl]-N-[(1S)-1-[[(1S)-1-carbamoyl-3-(methylthio)propyl]carbamoyl]-3-methyl-butyl]-N-methyl-pyrrolidine-2-carboxamide
(2S)-N-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-[(2S)-2-[[(2S)-2-(5-aminopentanoylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]-N-methylpyrrolidine-2-carboxamide
(2S)-N-[(2S)-1-[[(2S)-1-azanyl-4-methylsulfanyl-1-oxo-butan-2-yl]amino]-4-methyl-1-oxo-pentan-2-yl]-1-[(2S)-2-[[(2S)-2-(5-azanylpentanoylamino)-3-phenyl-propanoyl]amino]-3-phenyl-propanoyl]-N-methyl-pyrrolidine-2-carboxamide
[Molecular Formula]

C40H59N7O6S
[MDL Number]

MFCD00144411
[MOL File]

133156-06-6.mol
[Molecular Weight]

766
Chemical PropertiesBack Directory
[Boiling point ]

1082.2±65.0 °C(Predicted)
[density ]

1.198±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

Water:1.0(Max Conc. mg/mL);1.31(Max Conc. mM)
[form ]

Powder
[pka]

13.34±0.46(Predicted)
[color ]

White to off-white
[Water Solubility ]

Soluble to 1 mg/ml in water
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

GR 73632 is a NK1 tachykinin receptor agonist used in the treatment of asthma and gastrointestinal disorders. It is involved in the contraction of muscles.
[General Description]

Neurokinin (NK) receptors are acted upon by tachykinins or neurokinins namely, NKA and NKB. These are endogenous ligands. An exogenous agonist/ligand for NK1 is GR 64349 petpide.
[Biochem/physiol Actions]

GR 73632 interacts with neurokinin (NK1) receptor, which results in rhythmic tapping of hind-foot in gerbils. Administration of this peptide in the intra-ventral tegmental area (VTA) results in locomotor activity. It interacts with and activates NK1 receptors present on smooth muscle and interstitial cells of Cajal, resulting in elevated distention-induced peristalsis.
[storage]

Desiccate at -20°C
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