| Identification | Back Directory | [Name]
PHENETHICILLIN POTASSIUM SALT | [CAS]
132-93-4 | [Synonyms]
cvk
alpen
darcil
broxil
pen200
penova
pensig
brl152
brocsil
penemve
maxipen
optipen
semopen
synapen
peniplus
priospen
oralopen
chemipen
alticina
bendralan
ro-cillin
syncillin
synerpenin
alfacillin
alfocillin
chemipen-c
astracillin
dramcillin-s
synthecillin
penicillinmv
synthecilline
synthepentabl
feneticilline
penicillin-152
alpha-oralopen
alpha-oracillin
kphenethicillin
pheno-m-penicillin
penicillin B potassium
penicillin-152potassium
potassiumphenethicillin
pheneticillin potassium
PHENETHICILLIN POTASSIUM
PHENETHICILLIN POTASSIUM SALT
phenoxyaethylpenicillink-salz
potassium(1-phenoxyethyl)penicillin
alpha-phenoxyethylpenicillinpotassium
-heptane-2-carboxylicacidpotassiumsalt
potassiummethylphenoxymethylpenicillin
PHENETHICILLIN POTASSIUM SALT USP/EP/BP
potassium(alpha-phenoxyethyl)penicillin
alpha-phenoxyethylpenicillinpotassiumsalt
(2s-(2alpha,5alpha,6beta))-nopotassiumsal
PHENETICILLIN POTASSIUM WHO(CRM STANDARD)
α-Phenoxyethylpenicillinic acid, potassium
a-phenoxyethylpenicillinicacidpotassiumsalt
ALPHA-PHENOXYETHYLPENICILLINIC ACID POTASSIUM SALT
potassium6-(alpha-phenoxypropionamido)penicillanate
6-(a-phenoxypropionamido)penicillanicacidpotassiumsalt
6-[α-Phenoxypropionamido] penicillanic acid potassium salt
3,3-dimethyl-7-oxo-6--4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacimo
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-7-oxo-6-(2-p
3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenoxypropyl)amino]-4-thia-1-azabicyclo[3.2.0] | [EINECS(EC#)]
205-084-4 | [Molecular Formula]
C17H19KN2O5S | [MDL Number]
MFCD00082379 | [MOL File]
132-93-4.mol | [Molecular Weight]
402.51 |
| Hazard Information | Back Directory | [Originator]
Syncillin, Bristol, US ,1959 | [Definition]
ChEBI: Phenethicillin potassium is an organic potassium salt. It contains a phenethicillin(1-). | [Manufacturing Process]
Triethylamine (1.5 ml) was added to a cold solution (10°C) of αphenoxypropionic acid (1.66 g, 0.01 mol) in 15 ml of pure dioxane, with stirring and cooling to 5°C to 10°C while isobutyl chloroformate (1.36 g, 0.01 mol) in 5 ml of dioxane was added dropwise. Then the mixture was stirred for ten minutes at 5°C to 8°C. A solution of 6-amino-penicillanic acid (2.16 g, 0.01 mol) in 15 ml of water and 2 ml of triethylamine was then added dropwise while the temperature was maintained below 10°C. The resulting mixture was stirred in the cold for 15 minutes then at room temperature for 30 minutes, diluted with 30 ml of cold water and extracted with ether which was discarded. The cold aqueous solution was then covered with 75 ml of ether and acidified to pH 2 with 5 N H2SO4. After shaking, the ether layer containing the product 6-(α-phenoxypropionamido)penicillanic acid, was dried for ten minutes over anhydrous sodium sulfate and filtered. Addition of 6 ml of dry n-butanol containing 0.373 g/ml of potassium 2-ethylhexanoate precipitated the potassium salt of the product as a colorless oil which crystallized on stirring and scratching and was collected, dried in vacuo and found to weigh 2.75 g, to melt at 217°C to 219°C. | [Brand name]
Chemipen
(Bristol-Myers Squibb); Syncillin (Bristol-Myers
Squibb) [Name previously used: Phenethicillin.]. | [Therapeutic Function]
Antibacterial | [Safety Profile]
Poison by intravenous route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of K2O, SOx, and NOx. |
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