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ChemicalBook--->CAS DataBase List--->131602-24-9

131602-24-9

131602-24-9 Structure

131602-24-9 Structure
IdentificationBack Directory
[Name]

LG 83-6-05
[CAS]

131602-24-9
[Synonyms]

LG 83-6-05
[Molecular Formula]

C21H29NO3S
[MOL File]

131602-24-9.mol
[Molecular Weight]

375.525
Hazard InformationBack Directory
[Description]

LG 83-6-05 is a novel sodium channel blocking agent.
[Uses]

LG 83-6-05 is an inhibitor for sodium channel. LG 83-6-05 can be used in the research about cardiac rhythm disorders[1].
[in vivo]

In enzymatically-dispersed single ventricular cardiomyocytes of adult rats and guinea pigs the inhibition of the cardiac sodium current by a novel sodium channel blocking agent (LG 83-6-05, 1-[3-(2-Hydroxy-3-(2-methylpropylamino)-propoxy)-4-methyl-2- thienyl++ ]-3-phenyl-1-propanon hydrochloride) was studied. A single-electrode voltage-clamp system (switch clamping, patch electrodes) was used to measure action potentials as well as ionic currents during voltage-clamp experiments. In addition single channel measurements were performed using the patch-clamp technique. The single cell system enabled this study to demonstrate that LG 83-6-05 is an inhibitor of the cardiac sodium current._x000D_ _x000D_ Reference: Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):582-91. https://pubmed.ncbi.nlm.nih.gov/1965329/
[target]

LG 83-6-05 is a novel sodium channel blocking agent.
[References]

[1] Koidl B, Schreibmayer W, Wolf P, Tritthart HA. Inhibition of the fast sodium inward current in ventricular cardiomyocytes of rats and guinea pigs by a novel potent sodium channel blocking agent. Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):582-91. DOI:10.1007/BF00169049
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132798-26-6

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