Hazard Information | Back Directory | [Description]
LG 83-6-05 is a novel sodium channel blocking agent. | [Uses]
LG 83-6-05 is an inhibitor for sodium channel. LG 83-6-05 can be used in the research about cardiac rhythm disorders[1]. | [in vivo]
In enzymatically-dispersed single ventricular cardiomyocytes of adult rats and guinea pigs the inhibition of the cardiac sodium current by a novel sodium channel blocking agent (LG 83-6-05, 1-[3-(2-Hydroxy-3-(2-methylpropylamino)-propoxy)-4-methyl-2- thienyl++ ]-3-phenyl-1-propanon hydrochloride) was studied. A single-electrode voltage-clamp system (switch clamping, patch electrodes) was used to measure action potentials as well as ionic currents during voltage-clamp experiments. In addition single channel measurements were performed using the patch-clamp technique. The single cell system enabled this study to demonstrate that LG 83-6-05 is an inhibitor of the cardiac sodium current._x000D_
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Reference: Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):582-91. https://pubmed.ncbi.nlm.nih.gov/1965329/ | [target]
LG 83-6-05 is a novel sodium channel blocking agent. | [References]
[1] Koidl B, Schreibmayer W, Wolf P, Tritthart HA. Inhibition of the fast sodium inward current in ventricular cardiomyocytes of rats and guinea pigs by a novel potent sodium channel blocking agent. Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):582-91. DOI:10.1007/BF00169049 |
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