Identification | Back Directory | [Name]
N-[2-(1H-Indol-3-yl)ethyl]-4-(2-methyl-1H-indol-3-yl)-2-pyrimidinamine | [CAS]
1314594-23-4 | [Synonyms]
PKR-IN-C51 PKR inhibitor C51 PKR-inhibitor-C51 1H-Indole-3-ethanamine, N-[4-(2-methyl-1H-indol-3-yl)-2-pyrimidinyl]- N-[2-(1H-Indol-3-yl)ethyl]-4-(2-methyl-1H-indol-3-yl)-2-pyrimidinamine | [Molecular Formula]
C23H21N5 | [MOL File]
1314594-23-4.mol | [Molecular Weight]
367.45 |
Chemical Properties | Back Directory | [Boiling point ]
679.0±65.0 °C(Predicted) | [density ]
1.317±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 125 mg/mL (340.18 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
15.87±0.30(Predicted) | [color ]
Light yellow to yellow |
Hazard Information | Back Directory | [Uses]
PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages[1]. | [storage]
4°C, protect from light | [References]
[1] Ruslana Bryk, et al. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14. DOI:10.1016/j.bmcl.2011.04.149 |
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