1313730-14-1

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1313730-14-1 Structure

Identification	Back Directory
[Name] Teijin compound 1
[CAS] 1313730-14-1
[Synonyms] CCR2 antagonist 4 hydrochloride
[Molecular Formula] C21H22Cl2F3N3O2
[MOL File] 1313730-14-1.mol
[Molecular Weight] 476.32

Chemical Properties	Back Directory
[storage temp. ] Store at -20°C
[solubility ] Soluble to 10 mM in water and to 100 mM in DMSO
[form ] Powder
[color ] White to off-white

Hazard Information	Back Directory
[Uses] Teijin Compound 1 is a chemokine receptor, CCR2, inhibitor, which reduces sarcoma cell transendothelial migration and metastasis to the lungs.
[in vivo] In ApoE-deficient mice, Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta^[3].
[IC 50] CCR2b: 180 nM (IC₅₀)
[storage] Store at -20°C

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