| Identification | Back Directory | [Name]
Duocarmycin SA | [CAS]
130288-24-3 | [Synonyms]
CS-1375
Duocarmycin SA
Antibiotic DC 113
Cyclopropacpyrrolo3,2-eindole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (7bR)-
Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylicacid,1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-,methyl ester, (7bR,8aS)- | [Molecular Formula]
C25H23N3O7 | [MDL Number]
MFCD00870411 | [MOL File]
130288-24-3.mol | [Molecular Weight]
477.47 |
| Chemical Properties | Back Directory | [Boiling point ]
787.7±60.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.12±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Duocarmycin SA is an antitumor antibiotic. | [in vivo]
Duocarmycin SA (0.143 mg/kg, i.p., single dose) shows antitumor activity in murine lymphocytic leukemia P388 transplanted in CDF1 mice and shows a significant 30% increase in life span[3].
| Animal Model: | Murine lymphocytic leukemia P388 transplanted in CDF1 mice [3] | | Dosage: | 0.143 mg/kg | | Administration: | Intraperitoneal injection (i.p.), single dose | | Result: | Showed a significant 30% increase in life span.
|
| [IC 50]
Duocarmycins |
|
| Company Name: |
Abydos Scientific
|
| Tel: |
025-84767922 18936879710 |
| Website: |
http://www.abydoscientific.com/index.html |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|