Identification | Back Directory | [Name]
gidazepam | [CAS]
129186-29-4 | [Synonyms]
gidazepam Gidasepam Hidazepam Hydazepam 1H-1,4-Benzodiazepine-1-aceticacid, 7-bromo-2,3-dihydro-2-oxo-5-phenyl-, hydrazide | [Molecular Formula]
C17H15BrN4O2 | [MDL Number]
MFCD00947092 | [MOL File]
129186-29-4.mol | [Molecular Weight]
387.236 |
Chemical Properties | Back Directory | [Boiling point ]
675.6±55.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
12.37±0.37(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
Gidazepam is an agonist of GABA receptor channels (GABA RCs). | [in vivo]
Mice are distributed into 10 groups of five animals each, treated orally with Gidazepam (GDZ, 1 mg/kg); ester 1 (175 mg/kg); ester 2 (20 mg/kg); esters 3 and 4 (200 mg/kg); mixtures of Gidazepam and esters 1-4. All esters of GABA with monoterpenes display antiseizure effects in 3 h after oral administration as evidenced by increasing of inducing clonic-tonic convulsions (DCTC) and tonic extension (DTE) values. Gidazepam (1 mg/kg) is found to protect against seizures with DCTC and DTE values of 250% and 215%, accordingly; whereas co-administration of Gidazepam and esters 5-7 is shown to increase anticonvulsant activity compared with each compound alone[1]. | [References]
[1] N. Ya Golovenko, et al. Pharmacodynamical and Neuroreceptor Analysis of the Permeability of the Blood-Brain Barrier for Derivatives of 1,4-Benzodiazepine. Neurophysiology, Vol. 46, No. 3, June, 2014. [2] Nesterkina M, et al. Synthesis and Pharmacological Properties of Novel Esters Based on Monocyclic Terpenes and GABA. Pharmaceuticals (Basel). 2016 Jun 13;9(2). pii: E32. DOI:10.3390/ph9020032 |
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