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ChemicalBook--->CAS DataBase List--->128831-46-9

128831-46-9

128831-46-9 Structure

128831-46-9 Structure
IdentificationBack Directory
[Name]

1-[4-(2-chlorophenyl)-6,7-dimethyl-quinolin-3-yl]-3-(2,4-difluoropheny l)urea
[CAS]

128831-46-9
[Synonyms]

N-(4-(2-chlorophenyl)-6,7-dimethyl-3-quinolyl)-N'-(2,4-difluorophenyl)urea
1-[4-(2-chlorophenyl)-6,7-dimethyl-quinolin-3-yl]-3-(2,4-difluoropheny l)urea
Urea, N-[4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl]-N'-(2,4-difluorophenyl)-
[Molecular Formula]

C24H18ClF2N3O
[MDL Number]

MFCD00930481
[MOL File]

128831-46-9.mol
[Molecular Weight]

437.87
Chemical PropertiesBack Directory
[Melting point ]

approximate 217℃
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 10 mg/ml,DMSO: 30 mg/ml
[form ]

White solid.
Hazard InformationBack Directory
[Uses]

TMP-153 is an orally active inhibitor of ACAT with an IC50 value of approximately 5-10 nM against hepatic and intestinal ACAT in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis[1].
[References]

[1] Sugiyama Y, et al. TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. Atherosclerosis. 1995;113(1):71-78. DOI:10.1016/0021-9150(94)05429-m
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