| Identification | Back Directory | [Name]
3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine | [CAS]
128496-10-6 | [Synonyms]
3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine
3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-b-D-arabinouridine
3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine
1-(3',5'-Di-O-benzoyl-2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil
2,4(1H,3H)-Pyrimidinedione, 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
2,4(1H,3H)-PyriMidinedione, 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-b-D-arabinofuranosyl)-
1-(3,5-Di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
(2R,3R,4S,5R)-2-[(BENZOYLOXY)METHYL]-5-(2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-1-YL)-4-FLUOROOXOLAN-3-YL BENZOATE
((2R,3R,4S,5R)-3-(Benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate | [Molecular Formula]
C23H19FN2O7 | [MOL File]
128496-10-6.mol | [Molecular Weight]
454.4 |
| Chemical Properties | Back Directory | [Melting point ]
185-187 °C(Solv: chloroform (67-66-3); methanol (67-56-1)) | [density ]
1.45±0.1 g/cm3(Predicted) | [pka]
9.39±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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