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ChemicalBook--->CAS DataBase List--->12656-11-0

12656-11-0

12656-11-0 Structure

12656-11-0 Structure
IdentificationBack Directory
[Name]

TINZAPARIN SODIUM
[CAS]

12656-11-0
[Synonyms]

TINZAPARIN SODIUM
Chemical PropertiesBack Directory
[solubility ]

Dissolve 1.0 g in 10 mL of water R. The solution is clear (2.2.1) and not more intensely coloured than intensity 5 of the range of reference solutions of the most appropriate colour (2.2.2, Method II)
Hazard InformationBack Directory
[Uses]

Innohep (Pharmion).
[Clinical Use]


Peri- and postoperative surgical thromboprophylaxis
Treatment of DVT and pulmonary embolism
Prevention of thrombus formation in extracorporeal circulation during HD
[Drug interactions]

Potentially hazardous interactions with other drugs
Analgesics: increased risk of bleeding with NSAIDs - avoid concomitant use with IV diclofenac; increased risk of haemorrhage with ketorolac - avoid concomitant use.
Nitrates: anticoagulant effect reduced by infusions of glyceryl trinitrate.
Use with care in patients receiving oral anticoagulants, platelet aggregation inhibitors, aspirin or dextran.
[Metabolism]

Low molecular weight heparins are partially metabolised by desulphation and depolymerisation. The kidneys are the major site of tinzaparin excretion (approximately 70
% based on animal studies).
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