| Identification | Back Directory | [Name]
R 82150 | [CAS]
126320-77-2 | [Synonyms]
TIBO
R 82150
TIBO-R-82150
(5S)-6-(3-Methyl-2-butenyl)-4,5,6,7-tetrahydro-5α-methylimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione | [Molecular Formula]
C16H21N3S | [MDL Number]
MFCD00891666 | [MOL File]
126320-77-2.mol | [Molecular Weight]
287.423 |
| Hazard Information | Back Directory | [Description]
R 82150 is an antiviral drug and a member of the tetrahydroimidazo[4,5,1-jk]-[1,4]-benzodiazepin-2(1H)-thione family of compound. | [Uses]
R-82150 (TIBO-R 82150) is an HIV-1 reverse transcriptase inhibitor that blocks the reverse transcription of viral RNA by binding to the non-substrate binding site of reverse transcriptase, thereby inhibiting viral replication. R-82150 does not inhibit the replication of HIV-2, other RNA viruses, and DNA viruses[1]. | [References]
[1] Parker K A, et al. A four-step synthesis of TIBO R82150[J]. The Journal of Organic Chemistry, 1991, 56(15): 4600-4601. |
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