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ChemicalBook--->CAS DataBase List--->1257542-38-3

1257542-38-3

1257542-38-3 Structure

1257542-38-3 Structure
IdentificationBack Directory
[Name]

3-Cyclobutene-1,2-dione, 3-[(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)methyl]-4-(phenylamino)-
[CAS]

1257542-38-3
[Synonyms]

MCC1189
MCC-1189
MCC 1189
3-Cyclobutene-1,2-dione, 3-[(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)methyl]-4-(phenylamino)-
[Molecular Formula]

C22H20N2O2
[MOL File]

1257542-38-3.mol
[Molecular Weight]

344.41
Chemical PropertiesBack Directory
[Boiling point ]

456.1±55.0 °C(Predicted)
[density ]

1.327±0.06 g/cm3(Predicted)
[pka]

0.82±0.40(Predicted)
Hazard InformationBack Directory
[Description]

MCC1189 is a first-in-class inhibitor of MFS efflux pump CaMdr1p.
[Uses]

CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM[1].
[References]

[1] Keniya MV, et al., Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance. PLoS One. 2015 May 7;10(5):e0126350. DOI:10.1371/journal.pone.0126350
1257542-38-3 suppliers list
Company Name: TargetMol Chemicals Inc.
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Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
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Website: https://www.targetmol.cn/
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