| Identification | Back Directory | [Name]
Simeprevir sodium | [CAS]
1241946-89-3 | [Synonyms]
Olysio
Simeprevir sodium
TMC 435 sodium salt | [Molecular Formula]
C38H47N5O7S2.x(Na) | [MDL Number]
MFCD30724946 | [MOL File]
1241946-89-3.mol | [Molecular Weight]
773.94 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:30.0(Max Conc. mg/mL);38.86(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.43(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);38.86(Max Conc. mM) | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV. |
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