| Identification | Back Directory | [Name]
METHYLENE BLUE | [CAS]
122965-43-9 | [Synonyms]
CI 52015
CINO 52015
C.I. 52015 hydrate
MethyleneblueHydrat
METHYLENE BLUE HYDRATE
Basic Blue 9~C.I. 52015
METHYLENE BLUE EXTRA PURE
Methylene Blue, high purity
METHYLENE BLUE HYDRATE, PURE
METHYLENE BLUE FOR MICROSCOPY
Methylene Blue, biological stain
METHYLENE BLUE REDOX INDICATOR, REAG. PH . EUR.
METHYLENE BLUE TRIHYDRATE MOLECULAR*BIOL OGY REAGENT
Methylene Blue hydrate, high purity biological stain
Methylene Blue hydrate, Methylthionini chloridum
Methylene Blue hydrate,96+%,high purity biological stain
METHYLENE BLUE HYDRATE, HIGH PURITY BIOLOGICAL STAIN, 96+%
3,7-Bis(dimethylamino)phenothiazin-5-ium chloride hydrate(1:1:x)
Methylene Blue hydrate, high purity biological stain, 96+% 100GR
Methylene Blue hydrate[redox indicator, Reag. Ph. Eur., >=96% (calc. to the dried substance), 1038(S. No.), 52015(C.I.No)] | [EINECS(EC#)]
200-515-2 | [Molecular Formula]
C16H20ClN3OS | [MDL Number]
MFCD00150006 | [MOL File]
122965-43-9.mol | [Molecular Weight]
337.87 |
| Chemical Properties | Back Directory | [Appearance]
green fine crystalline powder | [Melting point ]
190 °C
| [storage temp. ]
room temp | [solubility ]
H2O: soluble4mg/4ml | [Colour Index ]
52015 | [form ]
Fine Crystalline Powder | [color ]
Green | [Water Solubility ]
Soluble in water, alcohol, acetic acid, glycerol and chloroform. Insoluble in ether. | [λmax]
661 nm | [Merck ]
14,6060 | [BRN ]
3599847 |
| Hazard Information | Back Directory | [Chemical Properties]
green fine crystalline powder | [Uses]
Methylene blue is used as a dye for a number of different staining procedures, such as Wright's stain and Jenner's stain. Since it is a temporary staining technique, methylene blue can also be used to examine RNA or DNA under the microscope or in a gel. I | [General Description]
Methylene Blue (MB) is a basic histological dye. | [Biochem/physiol Actions]
Methylene blue is used as a bacteriologic stain or dye and indicator. It mediates the inactivation of enveloped viruses in plasma, when exposed to visible light. It is an inhibitor of nitric oxide synthase and guanylate cyclase. It also plays a key role in medicine as an antimalarial agent, reducing agent in methemoglobinemia and inducer of apoptosis in cancer cells. | [in vivo]
Methylene blue (Basic Blue 9) hydrate (50 and 100 mg/kg; i.p.; once, for 25 min; male NMRI mice) reduces absent prepulse inhibition[1].
Methylene blue hydrate (20 and 40 mg/kg; p.o.; daily, for 6 months; CaMKIIα-tTA transactivator mice) preserves cognition in mice expressing full-length pro-aggregant human Tau[2].
Methylene blue hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces TBI-induced edema and neuroinflammation and reduces acute depression-like behavior[3].
Methylene blue hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces the percentage of inflammatory factor[3]. | Animal Model: | Male NMRI mice[1] | | Dosage: | 50 and 100 mg/kg | | Administration: | Intraperitoneal injection; once, for 25 minutes | | Result: | Reduced the prepulse inhibition and reduced the increase in locomotor activity caused by phencyclidine (PCP). |
| Animal Model: | CaMKIIα-tTA transactivator mice[2] | | Dosage: | 20 and 40 mg/kg | | Administration: | Oral administration; daily, for 6 months | | Result: | Inhibited Tau aggregation in CaMKIIα-tTA transactivator mice. |
| Animal Model: | TBI-treated male BALB/c mice[3] | | Dosage: | 2 mg/kg | | Administration: | Intravenous injection; once, for 1 day | | Result: | Decreased the level of CD14, IL-1β, TNF-α, and CCL2 mRNA. |
| Animal Model: | TBI-treated male BALB/c mice[3] | | Dosage: | 2 mg/kg | | Administration: | Intravenous injection; once, for 1 day | | Result: | Reduced the percentage of myeloid (CD11b+/GR1+) cells, reduced IL-1β and enhanced IL-10 expression in microglia. |
|
|
|