| Identification | Back Directory | [Name]
2-methylsulfinyl-4-methyl-6-[(3-methoxyphenyl)methyl]-4H-thieno[3,2-b]pyrrole[3,2-d]pyridazinone | [CAS]
1221186-52-2 | [Synonyms]
ML 202
2-methylsulfinyl-4-methyl-6-[(3-methoxyphenyl)methyl]-4H-thieno[3,2-b]pyrrole[3,2-d]pyridazinone | [Molecular Formula]
C18H17N3O3S2 | [MDL Number]
MFCD27991279 | [MOL File]
1221186-52-2.mol | [Molecular Weight]
387.48 |
| Chemical Properties | Back Directory | [Boiling point ]
673.0±65.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
-1.00±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ML202 is a highly specific allosteric activator of human pyruvate kinase M2 (hPK-M2), which can affect the cooperativity of phosphoenolpyruvate (PEP) binding, while adenosine diphosphate (ADP) binding almost no effect[1]. | [Definition]
ChEBI: 6-[(3-methoxyphenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone is an organosulfur heterocyclic compound, an organonitrogen heterocyclic compound and an organic heterobicyclic compound. | [References]
[1] Matthew B Boxer, et al. Identification of activators for the M2 isoform of human pyruvate kinase Version 3. 2009 Sep 1 [updated 2011 Mar 3]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID:21735594 |
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Tcichem, Inc.
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