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ChemicalBook--->CAS DataBase List--->1204737-09-6

1204737-09-6

1204737-09-6 Structure

1204737-09-6 Structure
IdentificationBack Directory
[Name]

THIIC
[CAS]

1204737-09-6
[Synonyms]

THIIC
LY2607540
LY-2607540
LY 2607540
[Molecular Formula]

C24H24F3N3O4
[MOL File]

1204737-09-6.mol
[Molecular Weight]

475.47
Hazard InformationBack Directory
[Description]

LY2607540, also known as THIIC, is a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties (EC(50) = 23 and 13 nM, respectively). THIIC produced anxiolytic-like efficacy in the rat stress-induced hyperthermia assay and the mouse stress-induced elevation of cerebellar cGMP and marble-burying assays. THIIC also produced robust activity in three assays that detect antidepressant-like activity, including the mouse forced-swim test, the rat differential reinforcement of low rate 72-s assay, and the rat dominant-submissive test, with a maximal response similar to that of imipramine.
[Uses]

THIIC (LY2607540) is a compound with anxiolytic and antidepressant potential. It is a positive allosteric modulator of mGlu receptors, exhibits anxiolytic and antidepressant-like activities in multiple animal models, and can also affect sleep and neurochemical changes.
[References]

[1] N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes DOI:10.1124/jpet.110.172957
1204737-09-6 suppliers list
Company Name: TargetMol Chemicals Inc.
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Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
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Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 021-13816613772 13816613772
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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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