| Identification | Back Directory | [Name]
CADP-RIBOSE | [CAS]
119340-53-3 | [Synonyms]
CADPR
C13050
CADP-RIBOSE
CYCLIC ADPR
CYCLIC ADP-RIBOSE
CADPR SODIUM SALT
cADP-Ribose (cADPR)
ADP-CYCLO-[N1:1'']-RIBOSE
CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE
CYCLIC ADENOSINE 5'-DIPHOSPHATE RIBOSE
CYCLIC ADP RIBOSE POTENT INTRACELLULAR
CYCLIC ADENOSINE DIPHOSPHATE RIBOSE SODIUM SALT
cyclicadenosinediphosphateribose(cadpr),sodiumsalt
Cyclic adenosine 5'-diphosphate ribose ammonium salt
cADP-Ribose (cADPR)
DISCONTINUED. Please see A291808.
ADP-cyclo[N1:1μμ]-ribose, cADP-ribose, cADPR, Cyclic ADPR
N-ALPHA-D-RIOFURANOSYL-P',5''-ESTER ADENOSINE 5'-(TRIHYDROGEN DIPHOSPHATE)
Adenosine5'-(trihydrogen diphosphate), 1-b-D-ribofuranosyl-, intramol. P',5''-ester
Adenosine 5'-(trihydrogen diphosphate), 1-β-D-ribofuranosyl-, intramol. P',5''-ester | [Molecular Formula]
C15H21N5O13P2 | [MDL Number]
MFCD00214262 | [MOL File]
119340-53-3.mol | [Molecular Weight]
541.3 |
| Chemical Properties | Back Directory | [Boiling point ]
934.8±75.0 °C(Predicted) | [density ]
2.57±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO (Slightly), Methanol (Very Slightly), Water (Slightly) | [form ]
lyophilized powder | [pka]
0.97±0.70(Predicted) | [color ]
White to off-white | [biological source]
(Ovotestis from sea hare) | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Cyclic adenosine diphosphate-ribose (cADPR) is an intracellular second messenger that mobilizes intracellular Ca2+ release from the sarcoplasmic reticulum through ryanodine receptors. CADPR is also a second messenger for glucose-induced insulin release from endocrine pancreas and for abscisic acid-induced calcium release in plants. | [Definition]
ChEBI: A cyclic purine nucleotide that is synthesised from NAD+ by ADP-ribosyl cyclase; acts as an agonist at ryanodine receptors. | [Biochem/physiol Actions]
Mobilizes intracellular Ca2+; regulates Ca2+-induced Ca2+?release specifically blocked by ryanodine; second messenger for glucose-induced insulin release from the endocrine pancreas and for abscisic acid-induced calcium release in plants. | [in vivo]
cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice[5]. | [storage]
-80°C |
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