| Identification | Back Directory | [Name]
Thiol-dPEG4-amie | [CAS]
1189760-69-7 | [Synonyms]
Thiol-PEG3-NH2
Thiol-PEG4-amine
Thiol-dPEG4-amie
HS-PEG3-CH2CH2NH2·HCl | [Molecular Formula]
C8H19NO3S | [MDL Number]
MFCD34470039 | [MOL File]
1189760-69-7.mol | [Molecular Weight]
209.31 |
| Hazard Information | Back Directory | [Biological Activity]
HS-PEG3-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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