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ChemicalBook--->CAS DataBase List--->1184847-16-2

1184847-16-2

1184847-16-2 Structure

1184847-16-2 Structure
IdentificationBack Directory
[Name]

JNJ-40413269 (JNJ40413269)
[CAS]

1184847-16-2
[Synonyms]

JNJ-40413269 (JNJ40413269)
[Molecular Formula]

C19H15ClF3N3O
[MOL File]

1184847-16-2.mol
[Molecular Weight]

393.79
Chemical PropertiesBack Directory
[Boiling point ]

522.8±50.0 °C(Predicted)
[density ]

1.398±0.06 g/cm3(Predicted)
[pka]

13.71±0.20(Predicted)
Hazard InformationBack Directory
[Description]

JNJ-40413269 is a competitive inhibitor of fatty acid amide hydrolase (FAAH), which demonstrates robust central target engagement, and shows efficacious in a rat model of neuropathic pain.
[Uses]

JNJ-40413269 is an inhibitor for FAAH, that inhibits human FAAH and rats FAAH with IC50 of 28 nM and 270 nM. JNJ-40413269 exhibits analgesic efficacy in rat spinal nerve ligation model and exhibits good pharmacokinetic characteristics in rats[1].
[References]

[1] Keith JM, et al., 1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1280-4. DOI:10.1016/j.bmcl.2014.01.064
1184847-16-2 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Tags:1184847-16-2 Related Product Information

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