| Identification | Back Directory | [Name]
BRL 44408 MALEATE | [CAS]
118343-19-4 | [Synonyms]
BRL 44408
BRL 44408 MALEATE
BRL 44408 maleate salt
2-[2H-(1-METHYL-1,3-DIHYDROISOINDOLE)METHYL]-4,5-DIHYDROIMIDAZOLE MALEATE
2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole
1H-Isoindole, 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-
2-[[(1-Methyl-1,3-dihydro-2H-isoindol)-2-yl]methyl]-4,5-dihydro-1H-imidazole
2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt
2-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-2,3-DIHYDRO-1-METHYL-1H-ISOINDOLE MALEATE
2-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1H-isoindole BRL 44408
Alendronate sodium trihydrate,4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217 | [Molecular Formula]
C13H17N3 | [MDL Number]
MFCD02262218 | [MOL File]
118343-19-4.mol | [Molecular Weight]
215.29 |
| Chemical Properties | Back Directory | [Boiling point ]
365.8±30.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
H2O: ~26 mg/mL, soluble | [form ]
solid | [pka]
10.29±0.40(Predicted) | [color ]
off-white | [Water Solubility ]
H2O: soluble 15mg/mL, clear |
| Hazard Information | Back Directory | [Uses]
BRL 44408 Maleate was used to study for norepinephrine reuptake modulators for preventing and treating vasomotor symptoms. | [Uses]
Selective a2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration | [Uses]
Selective α2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration. | [Biological Activity]
Selective α 2A -adrenoceptor antagonist (K i = 1.7 nM and 144.5 nM at α 2A and α 2B -adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α 2 -Adrenoceptor Tocriset™ . | [Biochem/physiol Actions]
BRL 44408 maleate is a selective α2A-adrenoceptor antagonist. | [References]
[1]. meana jj, callado lf, pazos a, et al. the subtype-selective alpha 2-adrenoceptor antagonists brl 44408 and arc 239 also recognize 5-ht1a receptors in the rat brain. eur j pharmacol, 1996, 312(3): 385-388.
[2]. owesson ca, seif i, mclaughlin dp, et al. different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-a knockout mice. eur j neurosci, 2003, 18(1): 34-42.
[3]. dwyer jm, platt bj, rizzo sj, et al. preclinical characterization of brl 44408: antidepressant- and analgesic-like activity through selective alpha2a-adrenoceptor antagonism. int j neuropsychopharmacol, 2010, 13(9): 1193-1205. |
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