| Identification | Back Directory | [Name]
1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE | [CAS]
117499-16-8 | [Synonyms]
dicarbamate
1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE
bis(2-tert-butyloxycarbonylaminoethyl)amine
Di-tert-butyl (azanediylbis(ethane-2,1-diyl)
N,N-Bis[2-(tert-butoxycarbonylaMino)ethyl]aMine
Di-tert-butyl (azanediylbis(ethane-2,1-diyl))dicarbaMate
10-Oxa-2,5,8-triazadodecanoic acid, 11,11-dimethyl-9-oxo-, 1,1-dimethylethyl ester
tert-butyl N-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]ethyl]carbamate | [Molecular Formula]
C14H29N3O4 | [MDL Number]
MFCD11226825 | [MOL File]
117499-16-8.mol | [Molecular Weight]
303.4 |
| Chemical Properties | Back Directory | [Melting point ]
68-70°C | [Boiling point ]
440.5±30.0 °C(Predicted) | [density ]
1.035±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [pka]
12.28±0.46(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE contains two Boc protecting groups which can be removed under acidic conditions. The remaining free amines can further react with carbonyl moieties. | [Chemical Properties]
1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE is white powder
| [Uses]
1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE is used in the preparation of bifunctional chelators that have been then applied to the synthesis of monoclonal antibody conjugates for tumor targeting.
| [in vitro]
1,7-Bis-Boc-1,4,7-triazaheptane is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins | [IC 50]
Alkyl/ether |
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