| Identification | Back Directory | [Name]
2-HYDROXYSACLOFEN | [CAS]
117354-64-0 | [Synonyms]
2-Oh-saclofen
HYDROXYSACLOFEN
2-HYDROXYSACLOFEN
2-Hydroxysaclofen solid
2-HYDROXYSACLOFEN, >99%
2-Hydroxysaclofen >=98% (TLC), solid
2-HYDROXYSACLOFEN ISO 9001：2015 REACH
2-HYDROXYSACLOFEN GABA(B) RECEPTOR ANTA
3-amino-2-(4-chlorophenyl)-2-hydroxy-*propanesulf
3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PRO PANESULFON
3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANE-SULFONIC ACID
3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonicaci
3-Amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid
3-Amino-2-hydroxy-2-(4-chlorophenyl)propane-1-sulfonic acid
(+/-)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPYLSULFONIC ACID
(RS)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPYL-SULFONIC ACID
(RS)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANESULPHONIC ACID
(+/-)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PROPANESULFONIC ACID
Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy-
beta-(Aminomethyl)-4-chloro-beta-hydroxybenzeneethanesulfonic acid
Benzeneethanesulfonic acid, beta-(aminomethyl)-4-chloro-beta-hydroxy- | [Molecular Formula]
C9H12ClNO4S | [MDL Number]
MFCD00069282 | [MOL File]
117354-64-0.mol | [Molecular Weight]
265.71 |
| Chemical Properties | Back Directory | [Melting point ]
267-269 °C | [RTECS ]
DA0359200 | [storage temp. ]
2-8°C | [solubility ]
H2O: 1 mg/mL | [form ]
solid | [color ]
white | [Water Solubility ]
Soluble in water at 1mg/ml. Also soluble in DMSO, 0.1M HCl and methanol |
| Hazard Information | Back Directory | [Uses]
2-Hydroxysaclofen is a GABA-B receptor antagonist in the ventral tegmental area and may play a role in the mechanisms of cocaine usage. Affects specific acute nicotine responses in mice, abolishing hypolocomotion and increasing antinociception. | [Definition]
ChEBI:3-amino-2-(4-chlorophenyl)-2-hydroxy-1-propanesulfonic acid is an organochlorine compound. | [Biological Activity]
Selective antagonist at GABA B receptors. | [in vivo]
2-Hydroxysaclofen (0.25-1 mg/kg; IP; single dosage) abolishes nicotine hypolocomotor effects and increases the antinociceptive effects of nicotine[1].
2-Hydroxysaclofen (0.3-3 mg/kg; IP; single dosage) reduces the effects of Baclofen (a GABA receptor agonist) on d-amphetamine-induced discriminative cue[2].
2-Hydroxysaclofen (0-100 μg/2 μl; ICV; single dosage) produces a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat[3]. | Animal Model: | Male Swiss Webster mice (22-24 g; treated with 3 mg/kg nicotine)[1] | | Dosage: | 0.25, 0.5 and 1 mg/kg | | Administration: | IP; single dosage; after 10 or 45 min of nicotine administration | | Result: | Abolished nicotine hypolocomotor effects at 1 mg/kg, and increased the antinociceptive effects of nicotine at 1 mg/kg. |
| Animal Model: | Male Wistar rats[2] | | Dosage: | 0.3, 1 and 3 mg/kg | | Administration: | IP; single dosage | | Result: | Reduced the effects of Baclofen on d-amphetamine-induced discriminative cue. |
| Animal Model: | Female Wistar rats (8 weeks)[3] | | Dosage: | 0, 20, 50 or 100 μg/2 μL | | Administration: | ICV; single dosage | | Result: | Produced a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat with a dose-dependent manner, and the peak LH values were observed 10 min after the injection.
The effect was dose-dependent, as 0 or 20 μg of the antagonist was ineffective while a pronounced effect was observed after the injection of 50 or 100 μg. |
| [storage]
Store at RT |
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