| Identification | Back Directory | [Name]
Norbinaltorphimine Dihydrochloride | [CAS]
113158-34-2 | [Synonyms]
(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol | [Molecular Formula]
C40H43N3O6.2HCl | [MOL File]
113158-34-2.mol | [Molecular Weight]
698.26 |
| Chemical Properties | Back Directory | [Melting point ]
>280 °C (decomp) | [storage temp. ]
Store at RT | [solubility ]
Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO | [form ]
Powder | [color ]
Light yellow to gray |
| Hazard Information | Back Directory | [Uses]
Norbinaltorphimine Dihydrochloride Salt is a synthetic derivative of Naltrexone (N285750, HCl) and is useful as a κ-opioid antagonist. | [Biological Activity]
Highly selective k-opioid receptor antagonist. nor-Binaltorphimine has antidepressant properties. | [in vivo]
Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well[2]. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement[3]. | [IC 50]
κ Opioid Receptor/KOR | [storage]
Store at RT |
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